Proton-coupled folate transporter pcft

Author: lfip

August undefined, 2024

WebbHere, entry is assumed to be primarily governed by the reduced folate carrier (RFC1, gene name: SLC19A1), and the proton-coupled folate transporter (PCFT, gene name: … Webb1 apr. 2024 · Elevated serum folate levels, like those seen in our patients, could also reflect changes in transport of folate in and out of cells. There are three main types of folate transporters: reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptors. Folate receptors have four isoforms: FRα, FRβ, FRγ, and FRδ [51 ...

Intraluminal Behavior of Various Transporter Substrates in the Rat ...

WebbThe proton-coupled folate transporter (PCFT), a member (SLC46A1) of the superfamily of solute transporters, harnesses the proton gradient as the energy source to achieve uphill … Webb1 apr. 2024 · Elevated serum folate levels, like those seen in our patients, could also reflect changes in transport of folate in and out of cells. There are three main types of folate … 動画 480p サイズ

Vitamin D3 and Its Nuclear Receptor Increase the Expression and ...

WebbPCFT operates most efficiently when there is a strong transmembrane pH gradient. Under these conditions transport of a folate molecule across the cell membrane is … WebbRecently, this laboratory identified a proton-coupled folate transporter (PCFT), with optimal activity at low pH. PCFT is critical to intestinal folate absorption and transport into the … Webb29 mars 2024 · The monomeric state of proton-coupled folate transporter is the functional state, substrate translocation does not depend on homo-oligomerization. PCFT is … 動画 2枚アプリ

Membrane Topological Analysis of the Proton-Coupled Folate …

Webb11 jan. 2024 · The proton-coupled folate transporter (PCFT) is widely expressed in human epithelial cancers (Zhao et al., 2004a;Desmoulin et al., 2011). Its low pH optimum favors … Webb26 maj 2024 · The proton-coupled folate transporter (PCFT) (also known as SLC46A1) mediates folate uptake across the intestinal brush border membrane and the choroid … avsとはWebbThe proton-coupled folate transporter (PCFT) plays a key role in intestinal folate absorption, and loss-of-function mutations in the gene encoding this transporter are the … 動画 40分ギガ

"WebbFolate is essential for DNA synthesis, repair and methylation. The uptake into cells is mediated by three transport mechanisms: The main transport is via the reduced folate … " - Proton-coupled folate transporter pcft

Proton-coupled folate transporter pcft

Intraluminal Behavior of Various Transporter Substrates in the Rat ...

WebbFolates are essential for nucleic acid synthesis and are particularly required in rapidly proliferating tissues, such as intestinal epithelium and hemopoietic cells. Availability of dietary folates is determined by their absorption across the intestinal epithelium, mediated by the proton-coupled folate transporter (PCFT) at the apical enterocyte membranes. Webb先天性葉酸吸収不全症は葉酸の輸送体であるproton-coupled folate transporter (PCFT)の機能喪失を原因とする常染色体劣性遺伝性疾患である。腸管からの葉酸吸収不全と脈絡膜における取り込み障害により, 乳児期早期から巨赤芽球性貧血, 免疫不全, 遷延性下痢, 精神発達遅滞, 痙攣などをきたす。大脳基底核に石灰化病変を認めることがある。 2．原因 …

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Webb6 juni 2024 · The proton-coupled folate transporter (PCFT) is a member (SLC46A1) of the superfamily of solute transporters. The major physiological roles of PCFT are in … Webb8 apr. 2024 · Elevated serum folate levels, like those seen in our patients, could also reflect changes in transport of folate in and out of cells. There are three main types of folate transporters: reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptors. Folate receptors have four isoforms: FRα, FRβ, FRγ, and FRδ

Webb10 nov. 2024 · This review considers the “promise” of exploiting the proton-coupled folate transporter (PCFT) for selective therapeutic targeting of cancer. PCFT was discovered in … WebbHowever, there were discrepancies between the properties of these transporters and characteristics of folate transport in many tissues, most notably the intestinal …

Webb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebbThe data suggested that E185 is required for proton coupling but, in its absence, the carrier is capable of function and exchange in the presence or absence of a proton-gradient. (4) …

WebbThe proton-coupled folate transporter (PCFT) (also known as SLC46A1) mediates folate uptake across the intestinal brush border membrane and the choroid plexus4,7, and is an …

Webb6 sep. 2012 · This review summarizes the biology of the proton-coupled folate transporter (PCFT). PCFT was identified in 2006 as the primary transporter for intestinal absorption … 動画 480p ビットレートWebbRecent studies have identified the proton-coupled folate transporter (PCFT) as the mechanism by which folates are absorbed across the apical brush-border membrane of … 動画 40分何ギガWebbFolate is essential for DNA synthesis, repair and methylation. The uptake into cells is mediated by three transport mechanisms: The main transport is via the reduced folate carrier (RFC), followed by the proton-coupled folate … avsとはトヨタWebbDual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates. Mol Cancer Ther. 2024 May;16(5):819-830. doi: 10.1158/1535-7163.MCT-16-0444. 動画 4k アップコンバートWebb5 jan. 2024 · This results in severe systemic and cerebral folate deficiency. 1-4 The disorder is due to mutations in the proton-coupled folate transporter (PCFT, SLC46A1) … avsとはパソコンWebb1 dec. 2001 · Protonation of residues in the outward open state primes the protein for transport (PubMed:34040256). Binding of folate promotes breaking of salt bridge … 動画 404エラーWebbFor methotrexate and PT523, uptake by RFC predominated even in the presence of PCFT or FRα. For both classic (methotrexate, PT523) and FRα-targeted (AGF102) antifolates, anti … 動画45分何ギガ